Pretreatment with lipopolysaccharide ameliorates Pseudomonas exotoxin A-induced hepatotoxicity in rats.

@article{Chiu2013PretreatmentWL,
  title={Pretreatment with lipopolysaccharide ameliorates Pseudomonas exotoxin A-induced hepatotoxicity in rats.},
  author={Chien-Chao Chiu and Yen-Te Huang and Yu-Chih Wang and Yi-Chih Chang and Yung-Hao Ching and Hans Hsien-Chuan Chen and Hsiao-Li Chuang},
  journal={Immunopharmacology and immunotoxicology},
  year={2013},
  volume={35 2},
  pages={296-303}
}
CONTEXT Liver injury can be induced by various hepatotoxicants, including Pseudomonas aeruginosa exotoxin A (PEA). Our previous study indicated that PEA-induced rat hepatotoxicity was T cells and Kupffer cells dependent. Several reports have demonstrated that non-toxic doses of bacterial lipopolysaccharide (LPS) can protect liver against the chemicals-induced toxicity such as acetaminophen and concanavalin-A. OBJECTIVE This study aimed to investigate the protecting mechanisms of LPS on PEA… CONTINUE READING