Pretreatment with isradipine, a calcium-channel blocker, does not attenuate the acute behavioral effects of ethanol in humans.

  title={Pretreatment with isradipine, a calcium-channel blocker, does not attenuate the acute behavioral effects of ethanol in humans.},
  author={Craig R Rush and Peggy J. Pazzaglia},
  journal={Alcoholism, clinical and experimental research},
  volume={22 2},
  • C. RushP. Pazzaglia
  • Published 1 April 1998
  • Medicine, Psychology
  • Alcoholism, clinical and experimental research
The acute subject-rated, performance-impairing, and physiological effects of ethanol (0, 0.5, and 1 g/kg) were examined after pretreatment with isradipine (0, 5, and 10 mg) in nine healthy volunteers. Volunteers received 1 of the 9 ethanol-isradipine combinations during each of nine experimental sessions. Ethanol alone produced prototypical subject-rated drug effects (e.g., increased ratings of "Drunk," "Good effects," and "Like drug") and impaired performance. Isradipine alone also produced… 

Pretreatment with hydromorphone, a mu-opioid agonist, does not alter the acute behavioral and physiological effects of ethanol in humans.

  • C. Rush
  • Medicine, Psychology
    Alcoholism, clinical and experimental research
  • 2001
The results of the present experiment suggest that hydromorphone pretreatment does not significantly affect the subject-rated effects of ethanol, and future human laboratory studies should test higher doses of hydromarphone.

Effects of L-type voltage-sensitive calcium channel modulators on the discriminative stimulus effects of ethanol in rats.

Results indicate that the administration of VGCC modulators plays an indirect role in the discriminative stimulus effects of ethanol.

L-Type Calcium Channel Blockers: A Potential Novel Therapeutic Approach to Drug Dependence

Preclinical evidence shows drugs that block particular calcium channels, the L-type, reduce dependence-related effects of alcohol, opioids, psychostimulants, and nicotine and could provide a novel approach to addiction treatment.

Alcohol Dependence Disrupts Amygdalar L-Type Voltage-Gated Calcium Channel Mechanisms

It is reported that acute alcohol increases CeA neuronal activity in naive rats by engaging L-type calcium channels (LTCCs) and that intra-CeA LTCC blockade reduces alcohol intake in nondependent rats.

Neuropharmacological treatments for alcoholism: scientific basis and clinical findings

Of the medications reviewed, acamprosate’s potential appears to be the most widely established and ondansetron, a serotonin3 antagonist, offers new hope for the treatment of early onset alcoholics; a type of alcoholism most difficult to manage with psychosocial measures alone.

Neuroplastic alterations in the limbic system following cocaine or alcohol exposure.

Evidence that drugs of abuse are powerful modulators of synaptic plasticity is reviewed, finding that dopaminergic neurons of the ventral tegmental area as well as medium spiny neurons in nucleus accumbens show enhanced excitatory synaptic strength following passive or active exposure to drugs such as cocaine and alcohol.

Gamma-aminobutyric acid(GABA)Receptors

This review focuses on receptors and channels that are often targeted by alcohol within the brain and discusses the general roles of these proteins, their role in alcohol-associated behaviors across species, and propose ways in which Drosophila models can help advance.



Modification of the behavioural effects of ethanol by nifedipine.

A clear interaction between nifedipine and ethanol which cannot be characterized as simple potentiation or antagonism is demonstrated and retardation of the development of acute tolerance may contribute to the interaction.

Effects of calcium antagonists on central actions of ethanol: comparative studies with nifedipine, verapamil and cinnarizine.

The effects of nifedipine, verapamil and cinnarizine on acute toxicity and central actions of ethanol, and effects of these drugs on the development of tolerance to hypothermic and sleep-inducing action of ethanol were studied in rats.

Isradipine and other calcium channel antagonists attenuate ethanol consumption in ethanol-preferring rats.

The data indicate that calcium channel antagonists exhibit quite different potency in reducing ethanol preference, however this action is a general property of this class of compounds.

Interaction between ethanol and calcium channel blockers in humans.

Results indicate that pretreatment with either verapamil or nifedipine failed to antagonize the inebriating effects of ethanol including its decremental effects on short-term memory and psychomotor performance.

Acute behavioral and cardiac effects of alcohol and caffeine, alone and in combination, in humans

Alcohol-caffeine combinations did not significantly alter breath alcohol levels, heart rate or subject-rated drug effects, relative to the effects of the drugs alone, documenting a high degree of consistency in the behavioral pharmacology of alcohol-stimulant combinations in humans.

Acute participant-rated and behavioral effects of alprazolam and buspirone, alone and in combination with ethanol, in normal volunteers.

It is suggested that the participant-rated effects of therapeutic doses of buspirone in combination with moderate doses of ethanol are similar to those of therapeutic dose of alprazolam in combination of ethanol, but the performance-impairing effects of busPirone are distinguishable from those of alPrazolham, alone and in combinationWith ethanol.

Blockade of ethanol discrimination by isradipine.