Pretreatment with hypertonic NaCl protects MDCK cells against high urea concentrations

  title={Pretreatment with hypertonic NaCl protects MDCK cells against high urea concentrations},
  author={Wolfgang Neuhofer and Eva A. Mueller and Anke Burger-Kentischer and Maria-Luisa Fraek and Klaus Thurau and F. X. Beck},
  journal={Pfl{\"u}gers Archiv},
 In antidiuresis, the cells of the renal medulla are exposed to high extracellular concentrations of NaCl and urea. Since urea equilibrates with the intracellular compartment and is known to perturb intracellular macromolecules, high urea concentrations may well disturb the structure and function of cell proteins. Two types of organic substances are believed to counteract the adverse effects of high intracellular urea concentrations: specific organic osmolytes of the trimethylamine family… CONTINUE READING


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