Pretreatment with antioxidants and allopurinol diminishes cardiac onset events in coronary artery bypass grafting.

@article{Sisto1995PretreatmentWA,
  title={Pretreatment with antioxidants and allopurinol diminishes cardiac onset events in coronary artery bypass grafting.},
  author={Tero Sisto and Hannu E. K. Paajanen and Timo Mets{\"a}-Ketel{\"a} and Aimo P. T. Harmoinen and Isto Nordback and Matti R. Tarkka},
  journal={The Annals of thoracic surgery},
  year={1995},
  volume={59 6},
  pages={1519-23}
}
Oxygen-derived free radicals constitute one part of the etiologic factors for cardiac onset harmful events. Allopurinol is able to reduce the generation of free radicals. Vitamins E and C scavenge radicals after their formation. Eighty-one patients with coronary artery disease were randomized into four study groups: Group 1 (n = 20) patients had stable disease and received oral vitamin E for 4 weeks, and vitamin C and allopurinol 2 days before and 1 day after coronary artery bypass grafting… CONTINUE READING
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