Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts.

@article{Liu1995PretreatmentWA,
  title={Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts.},
  author={Yongge Liu and Akihito Tsuchida and Michael V. Cohen and James M. Downey},
  journal={Journal of molecular and cellular cardiology},
  year={1995},
  volume={27 3},
  pages={883-92}
}
We have proposed that ischemic preconditioning in the rabbit heart is initiated by adenosine A1 receptor stimulation which results in an upregulation of protein kinase C (PKC). Subsequent sustained ischemia then causes renewed stimulation of adenosine A1 receptors with rapid reactivation of PKC and phosphorylation of a target protein(s) which mediates the protection. If the above theory is correct then angiotensin II (AII) receptor stimulation, which is known to activate PKC, should also… CONTINUE READING
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