Pretreatment with a γ-Secretase Inhibitor Prevents Tumor-like Overgrowth in Human iPSC-Derived Transplants for Spinal Cord Injury

@inproceedings{Okubo2016PretreatmentWA,
  title={Pretreatment with a γ-Secretase Inhibitor Prevents Tumor-like Overgrowth in Human iPSC-Derived Transplants for Spinal Cord Injury},
  author={Toshiki Okubo and Akio Iwanami and Jun Kohyama and Go Itakura and Soya Kawabata and Yuichiro Nishiyama and Keiko Sugai and Masahiro Ozaki and Tsuyoshi Iida and Kohei Matsubayashi and Morio Matsumoto and Masaya Nakamura and Hideyuki Okano},
  booktitle={Stem cell reports},
  year={2016}
}
Neural stem/progenitor cells (NS/PCs) derived from human induced pluripotent stem cells (hiPSCs) are considered to be a promising cell source for cell-based interventions that target CNS disorders. We previously reported that transplanting certain hiPSC-NS/PCs in the spinal cord results in tumor-like overgrowth of hiPSC-NS/PCs and subsequent deterioration of motor function. Remnant immature cells should be removed or induced into more mature cell types to avoid adverse effects of hiPSC-NS/PC… CONTINUE READING
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