Pretreatment with Mycobacterium avium-derived lipids attenuates the response of murine macrophages to components of Mycobacterium tuberculosis.

@article{Yang2012PretreatmentWM,
  title={Pretreatment with Mycobacterium avium-derived lipids attenuates the response of murine macrophages to components of Mycobacterium tuberculosis.},
  author={Daqing Yang and Yuan Liu and Yiguo Chen and Delong Jiao and Xiaorui Hou and Lei Wang and Ning Fu},
  journal={International journal of molecular medicine},
  year={2012},
  volume={29 6},
  pages={
          1072-82
        }
}
The high prevalence of Mycobacterium tuberculosis (MTB) despite widely available Bacille Calmette-Guerin (BCG) vaccination may be associated with Mycobacterium avium (M. avium), which may influence the host response to MTB. In this study, we demonstrate that pretreatment of murine macrophages with low-dose Mycobacterium avium-derived lipids (MALs), but not Escherichia coli-derived lipids (ELs), attenuates the clearance of intracellular Mycobacterium bovis BCG (M. bovis BCG) and the production… CONTINUE READING

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