Pretreatment or Resuscitation with a Lipid Infusion Shifts the Dose‐Response to Bupivacaine‐induced Asystole in Rats

@article{Weinberg1998PretreatmentOR,
  title={Pretreatment or Resuscitation with a Lipid Infusion Shifts the Dose‐Response to Bupivacaine‐induced Asystole in Rats},
  author={Guy L. Weinberg and T R Vadeboncouer and Gopal A. Ramaraju and M. F. Garcia-Amaro and Michael J. Cwik},
  journal={Anesthesiology},
  year={1998},
  volume={88},
  pages={1071–1075}
}
Background The authors sought to confirm a chance observation that intravenous lipid treatment increases the dose of bupivacaine required to produce asystole in rats. The authors also measured the partitioning of bupivacaine between the lipid and aqueous phases of a plasma‐lipid emulsion mixture. Methods Anesthetized Sprague‐Dawley rats were used in pretreatment (protocol 1) and resuscitation (protocol 2) experiments. In protocol 1, animals were pretreated with saline or 10%, 20%, or 30… 
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Epinephrine Administration in Lipid-based Resuscitation in a Rat Model of Bupivacaine-Induced Cardiac Arrest: Optimal Timing
TLDR
In the rat model of bupivacaine-induced cardiac arrest, the optimal timing for the administration of epinephrine to produce best outcomes of successful cardiopulmonary resuscitation is immediately after the completion of the lipid emulsion bolus.
Giving Priority to Lipid Administration Can Reduce Lung Injury Caused by Epinephrine in Bupivacaine-Induced Cardiac Depression
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Giving priority to the administration of a lipid emulsion before theadministration of epinephrine can reduce lung injury in bupivacaine-induced cardiac depression in rats.
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