Pretreatment of human colon tumor cells with DNA methylating agents inhibits their ability to repair chloroethyl monoadducts.

@article{Zlotogorski1984PretreatmentOH,
  title={Pretreatment of human colon tumor cells with DNA methylating agents inhibits their ability to repair chloroethyl monoadducts.},
  author={C Zlotogorski and Leonard C. Erickson},
  journal={Carcinogenesis},
  year={1984},
  volume={5 1},
  pages={83-7}
}
We have recently shown that a variety of human tumor cell lines are capable of preventing chloroethylnitrosourea (CNU)-induced DNA crosslinks, presumably by removing guanine O6-chloroethyl DNA monoadducts before crosslinks can form. Those cells capable of preventing crosslinking were of the Mer+ (Methylation repair) phenotype, and have been shown to be… CONTINUE READING