Pretreatment of donor islets with the Na(+) /Ca(2+) exchanger inhibitor improves the efficiency of islet transplantation.

@article{Mera2013PretreatmentOD,
  title={Pretreatment of donor islets with the Na(+) /Ca(2+) exchanger inhibitor improves the efficiency of islet transplantation.},
  author={Toshiyuki Mera and Takeshi Itoh and Sayaka Kita and Shohta Kodama and Daibo Kojima and Hitomi Nishinakamura and Kohji Okamoto and Masae Ohkura and Junko Nakai and Takuya Iyoda and Tsutomu Iwamoto and Takeru Matsuda and Akemi Baba and Keiko Omori and Junko Ono and Hiroshi Watarai and Masaru Taniguchi and Yohichi Yasunami},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2013},
  volume={13 8},
  pages={2154-60}
}
Pancreatic islet transplantation is an attractive therapy for the treatment of insulin-dependent diabetes mellitus. However, the low efficiency of this procedure necessitating sequential transplantations of islets with the use of 2-3 donors for a single recipient, mainly due to the early loss of transplanted islets, hampers its clinical application. Previously, we have shown in mice that a large amount of HMGB1 is released from islets soon after their transplantation and that this triggers… CONTINUE READING

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