Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium.

@article{Bartunek2007PretreatmentOA,
  title={Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium.},
  author={Jozef J. Bartunek and Jeffrey D Croissant and William Wijns and St{\'e}phanie Gofflot and Aurore de Lavareille and Marc Vanderheyden and Yulia Kaluzhny and Na{\"i}ma Mazouz and Philippe Willemsen and Martin Penicka and Myrielle Mathieu and Christian Homsy and Bernard de Bruyne and Kathleen McEntee and Ike W Lee and Guy R. Heyndrickx},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={292 2},
  pages={H1095-104}
}
The in vivo cardiac differentiation and functional effects of unmodified adult bone marrow mesenchymal stem cells (MSCs) after myocardial infarction (MI) is controversial. We postulated that ex vivo pretreatment of autologous MSCs using cardiomyogenic growth factors will lead to cardiomyogenic specification and will result in superior biological and functional effects on cardiac regeneration of chronically infarcted myocardium. We used a chronic dog MI model generated by ligation of the… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 34 references

Marrow stromal cells for cellular cardiomyoplasty: feasibility and potential clinical advantages.

The Journal of thoracic and cardiovascular surgery • 2000
View 4 Excerpts
Highly Influenced

A decade of discoveries in cardiac biology

E. Olson
Nat Med • 2004
View 2 Excerpts

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