Pretreatment of RPE Cells with Lutein Can Mitigate Bevacizumab-Induced Increases in Angiogenin and bFGF

  title={Pretreatment of RPE Cells with Lutein Can Mitigate Bevacizumab-Induced Increases in Angiogenin and bFGF},
  author={Natalia Vila and Jacqueline Coblentz and Carlos A. Moreira-Neto and Vasco Bravo-Filho and Pablo Zoroquia{\'i}n and Miguel N. Burnier, Jr.},
  journal={Ophthalmic Research},
  pages={48 - 53}
Purpose: To determine whether pretreatment of retinal pigmented epithelial (RPE) cells with lutein can affect the response of cells to bevacizumab therapy. Methods: One human RPE cell line (ARPE-19) was used for all experiments. The cells were treated with lutein in different concentrations (0.01, 0.1, 1, 10, or 100 μg/ml). After 24 h, all plates were treated with bevacizumab (0.25 mg/ml). Media were harvested 24 h later for sandwich ELISA-based angiogenesis arrays. A Quantibody Human… Expand
3 Citations
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  • A. Klettner, J. Roider
  • Biology, Medicine
  • Graefe's Archive for Clinical and Experimental Ophthalmology
  • 2009
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