Pretreatment of LPS inhibits IFN-β-induced STAT1 phosphorylation through SOCS3 induced by LPS.

@article{Ando2015PretreatmentOL,
  title={Pretreatment of LPS inhibits IFN-$\beta$-induced STAT1 phosphorylation through SOCS3 induced by LPS.},
  author={Takashi Ando and Takayuki Komatsu and Yoshikazu Naiki and Takashi. Yokochi and Daisuke Watanabe and Naoki Koide},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year={2015},
  volume={76},
  pages={
          1-5
        }
}
  • T. Ando, T. Komatsu, +3 authors N. Koide
  • Published 1 December 2015
  • Chemistry, Medicine
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
It has been known that LPS activates macrophages and induces IFN-β production from macrophages. The endogenous IFN-β produced by LPS stimulates the cells, which plays a role in innate immune. However, it was not elucidated yet if the signaling by exogenous IFN-β was influenced by LPS stimulation. In this study, it was found pretreatment of LPS interrupted IFN-β-induced JAK1/STAT1 phosphorylation. LPS pretreatment also reduced IFN-β-induced ISG54, one of IFN-β-inducible genes. Pretreatment with… Expand

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