Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461).

@article{Byrd2002PretreatmentCA,
  title={Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461).},
  author={John C. Byrd and Krzysztof Mr{\'o}zek and Richard K. Dodge and Andrew J. Carroll and Colin G. Edwards and Diane C. Arthur and Mark J. Pettenati and Shivanand R. Patil and Kathleen W. Rao and Michael S. Watson and Prasad Koduru and Joseph O. Moore and Richard M. Stone and Robert James Mayer and Eric J. Feldman and Frederick R. Davey and Charles A Schiffer and Richard A. Larson and Clara Derber Bloomfield},
  journal={Blood},
  year={2002},
  volume={100 13},
  pages={
          4325-36
        }
}
We analyzed prospectively 1213 adults with de novo acute myeloid leukemia (AML) to ascertain the prognostic impact of cytogenetic abnormalities on complete remission (CR) rate, 5-year cumulative incidence of relapse (CIR), and 5-year overall survival (OS). All patients received similar induction therapy. Median follow-up for surviving patients was 8.3 years. Nonprioritized cytogenetics distinguished t(8;21) and inv(16)/t(16;16) as conferring a significantly better prognosis than normal… Expand

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References

SHOWING 1-10 OF 77 REFERENCES
Isolated trisomy of chromosomes 8, 11, 13 and 21 is an adverse prognostic factor in adults with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B 8461.
TLDR
In de novo adult AML patients not receiving SCT, IT(C) appears to independently predict a poor outcome that may be improved with SCT in first remission, and Prospective studies are required to confirm this hypothesis. Expand
The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial.
TLDR
This study suggests that hierarchical cytogenetic classification identifies biologically distinct subsets of AML that are represented in all age groups, and highlights the importance of karyotype as a critical independent determinant of outcome in older patients with AML. Expand
Prognostic significance of karyotype in de novo adult acute myeloid leukemia. The BGMT group.
TLDR
A group of 201 adult patients with de novo acute myeloid leukemia were investigated to determine the prognostic significance of karyotype on early death, drug resistance, continuous complete remission (CCR) and survival probabilities at 5 years. Expand
Cytogenetics and their prognostic value in de novo acute myeloid leukaemia: a report on 283 cases
TLDR
The findings do not support the previously reported ‘favourable’ prognosis of t(15;17) translocations, but suggest that the prognosis associated with t(9;11) or its variants (at least in adults), and trisomy 8 might be less severe than suggested in other studies. Expand
The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties.
TLDR
Subgroup analysis demonstrated that the three cytogenetically defined prognostic groups retained their predictive value in the context of secondary as well as de novo AML, within the pediatric age group and furthermore were found to be a key determinant of outcome from autologous or allogeneic bone marrow transplantation (BMT) in first CR. Expand
Incidence of chromosome abnormalities and clinical significance of karyotype in de novo acute myeloid leukemia.
TLDR
The data suggest that cytogenetic findings should influence the therapeutic approach to AML, in particular, young patients with karyotypes associated with poor responses may be considered for more eradicating treatments, including allogenic bone marrow transplantation. Expand
Prognostic impact of cytogenetic abnormalities in patients with de novo acute nonlymphocytic leukemia.
TLDR
Detailed cytogenetic analyses were performed on specimens from 198 patients with de novo acute nonlymphocytic leukemia, including high-resolution banding studies in 79 patients, suggesting patients with abnormalities associated with poor responses may be considered for investigational approaches and may provide insights into mechanisms of drug resistance. Expand
Karyotype in acute myeloblastic leukemia: prognostic significance in a prospective study assessing bone marrow transplantation in first remission.
TLDR
It is shown that the karyotype retains its prognostic value when the intentions is to treat patients with acute myeloblastic leukemia in CR1 with BMT. Expand
Fifty-one patients with acute myeloid leukemia and translocation t(8;21)(q22;q22): an additional deletion in 9q is an adverse prognostic factor.
TLDR
The authors analyzed 51 cases of acute myeloid leukemia carrying a translocation t(8;21)(q22;q22); 23 female and 28 male patients and found the loss of a sex chromosome had no influence on prognosis, but a partial deletion of the long arm of chromosome 9 was an unfavorable prognostic factor. Expand
Patients with de novo acute myeloid leukaemia and complex karyotype aberrations show a poor prognosis despite intensive treatment: a study of 90 patients
TLDR
In conclusion, complex chromosome aberrations in de novo AML predicted a dismal outcome, even when patients were treated with intensive chemotherapy, and patients under the age of 60’years with complex aberrant karyotypes may benefit from HAM treatment during induction. Expand
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