Pretreatment 18F-FAZA PET predicts success of hypoxia-directed radiochemotherapy using tirapazamine.

Abstract

UNLABELLED We evaluated the predictive value of PET using the hypoxia tracer (18)F-fluoroazomycin arabinoside ((18)F-FAZA) for success of radiotherapy in combination with tirapazamine, a specific cytotoxin for hypoxic cells. METHODS Imaging was performed on EMT6 tumor-bearing nude mice before allocating mice into 4 groups: radiochemotherapy (RCT: 8… (More)

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@article{Beck2007Pretreatment1P, title={Pretreatment 18F-FAZA PET predicts success of hypoxia-directed radiochemotherapy using tirapazamine.}, author={Roswitha Beck and Barbara R{\"o}per and Janette Carlsen and Marc C. Huisman and Julia Aloisia Lebschi and Nicolaus Andratschke and Maria Cristina Picchio and Michael Souvatzoglou and Hans-J{\"u}rgen Machulla and Morand Piert}, journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, year={2007}, volume={48 6}, pages={973-80} }