Pretransplantation liver function impacts on the outcome of allogeneic hematopoietic stem cell transplantation: a study of 455 patients.

@article{Barba2011PretransplantationLF,
  title={Pretransplantation liver function impacts on the outcome of allogeneic hematopoietic stem cell transplantation: a study of 455 patients.},
  author={Pere Barba and Jos{\'e} Luis Pi{\~n}ana and Francesc Fern{\'a}ndez-Avil{\'e}s and Jos{\'e} Antonio P{\'e}rez-Sim{\'o}n and Rodrigo Martino and Eva L{\'o}pez-Guerrero and David Valc{\'a}rcel and Montserrat Comas Rovira and Silvana Novelli and Isabel Campos-Varela and Luc{\'i}a L{\'o}pez-Anglada and Xavier Krauel Vidal and Luc{\'i}a L{\'o}pez Corral and Enric Carreras and Jorge Sierra},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2011},
  volume={17 11},
  pages={
          1653-61
        }
}
Liver dysfunction is frequent before allogeneic stem cell transplantation (allo-SCT). However, its characteristics and impact on transplantation outcomes are uncertain, especially in the reduced-intensity conditioning (RIC) setting. We analyzed 455 patients receiving an allo-SCT in 3 Spanish centers. Pretransplantation aspartate aminotransferase (AST), alanine aminotransaminase (ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (AP), total bilirubin, and international normalized… CONTINUE READING