Pretransplant sensitization against angiotensin II type 1 receptor is a risk factor for acute rejection and graft loss.

@article{Giral2013PretransplantSA,
  title={Pretransplant sensitization against angiotensin II type 1 receptor is a risk factor for acute rejection and graft loss.},
  author={Magali Giral and Yohann Foucher and Alexandre Dufay and Jean-Paul Duong van Huyen and Karine Renaudin and Anne 4 Moreau and A C Philippe and Bj{\"o}rn Hegner and Ralf Dechend and Harald Heidecke and Sophie Brouard and Anne Cesbron and St{\'e}phanie Castagnet and Anne Devys and J P Soulillou and Duska Dragun},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2013},
  volume={13 10},
  pages={2567-76}
}
The angiotensin II type 1 receptor (AT1R) is an emerging target of functional non-HLA antibodies (Ab). We examined the potential of determining the degree of presensitization against AT1R as a risk factor for graft survival and acute rejection (AR). The study included 599 kidney recipients between 1998 and 2007. Serum samples were analyzed in a blinded fashion for anti-AT1R antibodies (AT1R-Abs) using a quantitative solid-phase assay. A threshold of AT1R-Ab levels was statistically determined… CONTINUE READING

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