Prethymic T cell precursors express receptors for antigen.

  title={Prethymic T cell precursors express receptors for antigen.},
  author={Robert P Chervenak and John W. Moorhead and J. John Cohen},
  journal={Journal of immunology},
  volume={134 2},
An anti-idiotype serum raised in BALB/c mice against syngeneic lymph node T cells from 2,4-dinitrofluorobenzene (DNFB)-sensitized mice was used to study the early expression of antigen receptors on developing T cells. Normal BALB/c bone marrow cells were treated with either anti-Thy-1.2 plus complement or anti-Thy-1.2 and anti-idiotype plus complement before use in the reconstitution of lethally irradiated syngeneic mice. Five weeks after reconstitution, recipient mice were assayed for both… CONTINUE READING