Pretherapy nuclear factor-kappaB status, chemoradiation resistance, and metastatic progression in esophageal carcinoma.

@article{Izzo2006PretherapyNF,
  title={Pretherapy nuclear factor-kappaB status, chemoradiation resistance, and metastatic progression in esophageal carcinoma.},
  author={Julie G. Izzo and Arlene M. Correa and Tsung-Teh Wu and Usha Malhotra and Clifford K S Chao and Rajyalakshmi Luthra and Joe Ensor and Alexander A. Dekovich and Zhongxing Liao and Walter N. Hittelman and Bharat Bhushan Aggarwal and Jaffer A. Ajani},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 11},
  pages={2844-50}
}
BACKGROUND Transcriptional factor nuclear factor-kappaB (NF-kappaB) seems to be associated with aggressive clinical biology (chemoradiation resistance and metastatic progression) of esophageal cancer. We hypothesized that activated NF-kappaB would define clinical biology irrespective of the type of chemotherapy or sequence administered. METHODS Pretherapy and/or posttherapy cancer specimens were examined for activated NF-kappaB and correlated with pathologic response to chemoradiation… CONTINUE READING

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