Preterm neonatal cardiovascular instability: does understanding the fetus help evaluate the newborn?

  title={Preterm neonatal cardiovascular instability: does understanding the fetus help evaluate the newborn?},
  author={Laura Bennet and Lindsea Booth and Paul P. Drury and Josine S L T Quaedackers and Alistair J. Gunn},
  journal={Clinical and experimental pharmacology & physiology},
  volume={39 11},
Preterm newborns, particularly very low birth weight newborns, frequently experience intermittent hypotension and/or hypoperfusion. Organ perfusion is largely distinct from systemic hypotension, suggesting that changes in underlying vascular tone are the major determinants of perfusion. Preterm fetuses have a remarkable anaerobic tolerance and ability to survive major insults with no or limited injury, balanced by relative immaturity of key autonomic responses. Exposure to hypoxia-ischaemia and… CONTINUE READING


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