Pretargeted radioimmunotherapy with a single-chain antibody/streptavidin construct and radiolabeled DOTA-biotin: strategies for reduction of the renal dose.

@article{Frster2006PretargetedRW,
  title={Pretargeted radioimmunotherapy with a single-chain antibody/streptavidin construct and radiolabeled DOTA-biotin: strategies for reduction of the renal dose.},
  author={Gregor J. F{\"o}rster and E. M. B. Santos and Peter M. Smith-Jones and Pat Zanzonico and Steven M. Larson},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2006},
  volume={47 1},
  pages={140-9}
}
UNLABELLED Multistep immune targeting holds great promise for radioimmunodiagnosis and therapy of cancer. Pretargeting of the tetrameric single-chain, variable-fragment streptavidin construct of the tetrameric monoclonal antibody CC49 with subsequent administration of radiolabeled 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA)-biotin has yielded promising results in TAG-72-expressing tumor xenograft models. A potential limitation of this approach, however, has been high… CONTINUE READING

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