Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons.

@article{Katona1999PresynapticallyLC,
  title={Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons.},
  author={Istv{\'a}n Katona and Be{\'a}ta Sperl{\'a}gh and Attila S{\'i}k and A K{\"a}falvi and E. Sylvester Vizi and Ken Mackie and Tam{\'a}s F. Freund},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 11},
  pages={4544-58}
}
To understand the functional significance and mechanisms of action in the CNS of endogenous and exogenous cannabinoids, it is crucial to identify the neural elements that serve as the structural substrate of these actions. We used a recently developed antibody against the CB1 cannabinoid receptor to study this question in hippocampal networks. Interneurons with features typical of basket cells showed a selective, intense staining for CB1 in all hippocampal subfields and layers. Most of them (85… CONTINUE READING
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