Presynaptic sympathetic mechanism in the insulinostatic effect of epinephrine in mouse pancreatic islets.

@article{Karlsson1997PresynapticSM,
  title={Presynaptic sympathetic mechanism in the insulinostatic effect of epinephrine in mouse pancreatic islets.},
  author={Staffan Karlsson and U. Myrs{\'e}n and Arie G Nieuwenhuizen and Frank Sundler and Bo Ahr{\'e}n},
  journal={The American journal of physiology},
  year={1997},
  volume={272 5 Pt 2},
  pages={R1371-8}
}
The catecholamines inhibit insulin release. It is not established whether presynaptic mechanisms contribute to this effect. We therefore examined the relative contribution of presynaptic and postsynaptic mechanisms to the insulinostatic effects of epinephrine and norepinephrine. Mice were injected with 6-hydroxydopamine (6-OHDA; 0.19 mmol/kg) or its vehicle. Islets were isolated after 48 h. Islets from vehicle-injected control animals contained numerous tyrosine hydroxylase (TH)-immunoreactive… CONTINUE READING