Presynaptic serotonin receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock

@article{Goodwin1985PresynapticSR,
  title={Presynaptic serotonin receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock},
  author={Guy M. Goodwin and Rosemarie J. De Souza and Alfred Richard Green},
  journal={Nature},
  year={1985},
  volume={317},
  pages={531-533}
}
Ligand-binding studies have demonstrated two types of serotonin (5-HT) receptor, 5-HT1 and 5-HT2, in the brains of rodents1 and there is additional evidence for the existence of 5-HT1 subtypes2,3. Recently a new drug, 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT), has been identified which shows high selectivity for binding to 5-HT1 (possibly 5-HT1A) receptors3 and which binds to presynaptic serotonin autoreceptors in some regions of rat brain4,5. We have shown previously, that this… CONTINUE READING

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