Presynaptic serotonergic markers in community-acquired cases of Alzheimer's disease: correlations with depression and neuroleptic medication.

@article{Chen1996PresynapticSM,
  title={Presynaptic serotonergic markers in community-acquired cases of Alzheimer's disease: correlations with depression and neuroleptic medication.},
  author={Christopher Chen and Jacqueline Alder and David M. Bowen and Margaret M. Esiri and Brendan Mcdonald and Terry Hope and Kim A. Jobst and Paul T Francis},
  journal={Journal of neurochemistry},
  year={1996},
  volume={66 4},
  pages={
          1592-8
        }
}
Presynaptic serotonergic markers, serotonin uptake sites, and concentrations of serotonin and 5-hydroxyindoleacetic acid were studied in the frontal and temporal cortex of 20 community-acquired cases of Alzheimer's disease and 16 controls matched for age, sex, postmortem delay, and storage. Clinical assessments, including behavioural symptoms, of the Alzheimer patients were made at 4-month intervals during life. There was significant reduction in the number of serotonin uptake sites in… CONTINUE READING

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