Presynaptic regulation of glutamate release in the ventral tegmental area during morphine withdrawal.

@article{Manzoni1999PresynapticRO,
  title={Presynaptic regulation of glutamate release in the ventral tegmental area during morphine withdrawal.},
  author={Oliver J Manzoni and John Michael Williams},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 15},
  pages={6629-36}
}
The regulation of glutamate (Glu) release from the excitatory input to dopamine cells in the ventral tegmental area (VTA) during acute withdrawal from morphine was studied in slices from animals treated for 6-7 d with morphine. EPSCs were inhibited by opioid agonists acting at micro-subtype receptors but not by selective delta- or kappa-subtype agonists. The opioid inhibition was reduced by 65% with the potassium channel blocker 4-aminopyridine (4-AP; 100 microM) and a 12-lipoxygenase inhibitor… CONTINUE READING
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