Presynaptic regulation of glutamate release from guinea-pig cortical synaptosomes

@inproceedings{Barrie1988PresynapticRO,
  title={Presynaptic regulation of glutamate release from guinea-pig cortical synaptosomes},
  author={Anne P. Barrie and David G. Nicholls},
  year={1988}
}
min). By this time the ATP level has dropped too low for the energy-dependent process of exocytosis to occur. A drop in plasma membrane potential of 1.7 mV/min causes an increase in the Ca? +-independent release of glutamate due to the reversal of the Na+ -glutamate co-transporter. These results reinforce the very stringent energy dependence of glutamate exocytosis already reported by SanchezPneto et al. (1987). We also conclude that the Ca2'independent release of metabolic glutamate is likely… CONTINUE READING

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