Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasion.

@article{Dodson2003PresynapticRK,
  title={Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasion.},
  author={Paul D Dodson and Brian Billups and Zolt{\'a}n Ruszn{\'a}k and G{\'e}za Szűcs and Matthew C Barker and Ian D. Forsythe},
  journal={The Journal of physiology},
  year={2003},
  volume={550 Pt 1},
  pages={27-33}
}
Voltage-gated K+ channels activating close to resting membrane potentials are widely expressed and differentially located in axons, presynaptic terminals and cell bodies. There is extensive evidence for localisation of Kv1 subunits at many central synaptic terminals but few clues to their presynaptic function. We have used the calyx of Held to investigate the role of presynaptic Kv1 channels in the rat by selectively blocking Kv1.1 and Kv1.2 containing channels with dendrotoxin-K (DTX-K) and… CONTINUE READING
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