Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila.

  title={Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila.},
  author={Rickard Ignell and Cory M. Root and Ryan T Birse and Jing W. Wang and Dick R N{\"a}ssel and Asa M E Winther},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 31},
The role of classical neurotransmitters in the transfer and processing of olfactory information is well established in many organisms. Neuropeptide action, however, is largely unexplored in any peripheral olfactory system. A subpopulation of local interneurons (LNs) in the Drosophila antannal lobe is peptidergic, expressing Drosophila tachykinins (DTKs). We show here that olfactory receptor neurons (ORNs) express the DTK receptor (DTKR). Using two-photon microscopy, we found that DTK applied to… CONTINUE READING
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Expression and functional characterization of a Drosophila neuropeptide precursor with homology to mammalian preprotachykinin A

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