Presynaptic nicotinic ACh receptors

@article{Wonnacott1997PresynapticNA,
  title={Presynaptic nicotinic ACh receptors},
  author={Susan Wonnacott},
  journal={Trends in Neurosciences},
  year={1997},
  volume={20},
  pages={92-98}
}
  • S. Wonnacott
  • Published 1 February 1997
  • Biology
  • Trends in Neurosciences

Nicotinic Acetylcholine Receptors in Neurons

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Presynaptic Nicotinic Acetylcholine Receptors: Subtypes and Functions

Results are summarized for nAChR-mediated 86Rb+ efflux as well as nA ChR- mediated dopamine, GABA, glutamate, norepinephrine, and ACh release for neurotransmitters and neuropeptides.

Getting past the asterisk: the subunit composition of presynaptic nicotinic receptors that modulate striatal dopamine release.

  • C. Luetje
  • Biology, Chemistry
    Molecular pharmacology
  • 2004
Nicotinic acetylcholine receptors (nAChRs), despite wide distribution, do not play a major role in direct mediation of central synaptic transmission and are primarily involved in modulating the release of neurotransmitters.

Localization of neuronal nicotinic acetylcholine receptor subunits in rat substantia nigra and dorsal striatum

Nicotinic acetylcholine receptors (nAChR) belong to the cys-loop superfamily of ligand-gated ion channels whose other members include GABAA, GABAC, glycine, and 5-HT3 receptors. nAChR are composed of

Molecular Diversity of Neuronal Nicotinic Acetylcholine Receptors

  • D. McGehee
  • Biology, Chemistry
    Annals of the New York Academy of Sciences
  • 1999
This review outlines the current understanding of the molecular constituents of these receptors and some of the recent studies of the structural determinants of receptor function.

Presynaptic neuronal nicotinic receptors : Pharmacology, heterogeneity, and cellular mechanisms

This chapter aims to summarise the evidence for presynaptic nAChRs and to consider the cellular mechanisms relating to their activation and the implications for synaptic functioning.

Allosteric modulation of neuronal nicotinic acetylcholine receptors

Presynaptic Nicotinic Acetylcholine Receptors and the Modulation of Circuit Excitability

This review focuses entirely on the contribution of presynaptic nAChRs to the regulation and dysregulation of synapses and circuits in the CNS.

Assembly and trafficking of nicotinic acetylcholine receptors (Review)

This review will discuss nAChR subunit diversity and factors influencing receptor assembly and trafficking.
...

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In the present study, three different monoclonal antibodies raised against the α7 subunit were used to map its distribution throughout the central nervous system of the rat.

Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors.

Findings reveal that CNS nAChRs enhance fast excitatory transmission, providing a likely mechanism for the complex behavioral effects of nicotine.

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Since Langley’ first reported the existence of a “receptive substancc” for nicotine in skeletal muscle that could mediatc the effccts of nicotine, evidence was obtained that acetylcholinc receptors

Existence of different subtypes of nicotinic acetylcholine receptors in the rat habenulo-interpeduncular system

In contrast, nAChRs recorded on the soma of MHB neurons under equivalent experimental conditions exhibited different characteristics for single-channel conductance and agonist and antagonist sensitivity, demonstrating the functional diversity of nA ChRs in the rat CNS.

Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit.

It is suggested that cytisine is a true partial agonist for beta 2-containing ACh receptors and as such can inhibit the response of these receptors to ACh through a competitive mechanism.
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