Presynaptic muscarinic receptors and the release of acetylcholine from cerebrocortical prisms: roles of Ca2+ and K+ concentrations

@article{Doleal1993PresynapticMR,
  title={Presynaptic muscarinic receptors and the release of acetylcholine from cerebrocortical prisms: roles of Ca2+ and K+ concentrations},
  author={Vladim{\'i}r Dole{\vz}al and Stanislav Tu{\vc}ek},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1993},
  volume={348},
  pages={228-233}
}
The mechanism by which presynaptic muscarinic autoreceptors inhibit the release of acetylcholine (ACh) from cerebrocortical cholinergic fibres has not been clarified. To test the view that muscarinic autoreceptors act by decreasing Ca2+ influx, we performed experiments in which rat cerebrocortical prisms were preloaded with (14C)choline, washed, depolarized… CONTINUE READING