Presynaptic mechanisms underlying cannabinoid inhibition of excitatory synaptic transmission in rat striatal neurons.

@article{Huang2001PresynapticMU,
  title={Presynaptic mechanisms underlying cannabinoid inhibition of excitatory synaptic transmission in rat striatal neurons.},
  author={C C Huang and Sze Wan Lo and Kuei-Sen Hsu},
  journal={The Journal of physiology},
  year={2001},
  volume={532 Pt 3},
  pages={731-48}
}
The striatum is a crucial site of action for the motor effects of cannabinoids (CBs). However, the electrophysiological consequences of activation of CB receptors on the striatal neurons have not been established. Here we report for the first time that the cannabimimetic aminoalkylindole WIN 55,212-2 and the endogenous cannabinoid anandamide substantially depress corticostriatal glutamatergic synaptic transmission onto striatal neurons in the brain slice preparation. The selective CB1 receptor… CONTINUE READING
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