Presynaptic leptin action suppresses excitatory synaptic transmission onto ventral tegmental area dopamine neurons.

@article{Thompson2013PresynapticLA,
  title={Presynaptic leptin action suppresses excitatory synaptic transmission onto ventral tegmental area dopamine neurons.},
  author={Jennifer Laurie Thompson and Stephanie L Borgland},
  journal={Biological psychiatry},
  year={2013},
  volume={73 9},
  pages={860-8}
}
BACKGROUND Leptin is an adipocyte-derived cytokine that can act in the brain to suppress feeding and maintain energy homeostasis. Additionally, leptin activates its receptors in the ventral tegmental area (VTA), a critical site for neuroadaptations to rewarding stimuli, to modulate reward-seeking behaviors. Although leptin can decrease intrinsic excitability of dopamine neurons in the VTA, it is unknown whether leptin can modulate excitatory synaptic transmission in this brain region. Because… CONTINUE READING

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