Presynaptic inhibitory actions of pregabalin on excitatory transmission in superficial dorsal horn of mouse spinal cord: Further characterization of presynaptic mechanisms

@article{Matsuzawa2014PresynapticIA,
  title={Presynaptic inhibitory actions of pregabalin on excitatory transmission in superficial dorsal horn of mouse spinal cord: Further characterization of presynaptic mechanisms},
  author={Rie Matsuzawa and Tomonori Fujiwara and Kohei Nemoto and Teruyuki Fukushima and Shigeki Yamaguchi and Kimio Akagawa and Yuuichi Hori},
  journal={Neuroscience Letters},
  year={2014},
  volume={558},
  pages={186-191}
}
Pregabalin is widely used as an analgesic for the treatment of neuropathic pain. In the present experiments using mouse spinal slices, we recorded electrically evoked glutamatergic excitatory postsynaptic currents (eEPSCs) from superficial dorsal horn neurons. Pregabalin reduced the amplitude of eEPSCs, and increased the paired pulse ratio. Pregabalin also inhibited the frequency of spontaneously occurring miniature EPSCs without affecting their amplitude. Partial ligation of the sciatic nerve… CONTINUE READING