Presynaptic inhibition of elicited neurotransmitter release.

  title={Presynaptic inhibition of elicited neurotransmitter release.},
  author={Li Guo Wu and Peter Saggau},
  journal={Trends in neurosciences},
  volume={20 5},
Activation of presynaptic receptors for a variety of neurotransmitters and neuromodulators inhibits transmitter release at many synapses. Such presynaptic inhibition might serve as a means of adjusting synaptic strength or preventing excessive transmitter release, or both. Previous evidence showed that presynaptic modulators inhibit Ca2+ channels and activate K+ channels at neuronal somata. These modulators also inhibit spontaneous transmitter release by mechanisms downstream of Ca2+ entry. The… CONTINUE READING
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