Presynaptic inhibition by muscimol through GABAB receptors.

  title={Presynaptic inhibition by muscimol through GABAB receptors.},
  author={Toshimasa Yamauchi and Tetsuya Hori and Tomoyuki Takahashi},
  journal={The European journal of neuroscience},
  volume={12 9},
The gamma-aminobutyric acid type A (GABAA) receptor agonist muscimol is widely used as a tool for reducing neuronal activities particularly in experiments in vivo. At the synapse formed by the calyx of Held in the rat brainstem slice, the GABAA receptor agonist muscimol (> 10 microM) attenuated the amplitude of excitatory post synaptic currents (EPSCs) accompanied by an increase in the coefficient of variation of EPSCs, suggesting its presynaptic inhibitory effect. This muscimol effect was not… CONTINUE READING