Presynaptic influence on the time course of fast excitatory synaptic currents in cultured hippocampal cells.

@article{Mennerick1995PresynapticIO,
  title={Presynaptic influence on the time course of fast excitatory synaptic currents in cultured hippocampal cells.},
  author={Steven J Mennerick and Charles F Zorumski},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1995},
  volume={15 4},
  pages={3178-92}
}
Since the lifetime of synaptically released glutamate is thought to be very brief, reflecting diffusion and glutamate uptake, the decay of synaptic currents is thought to represent the average elementary lifetime of a receptor channel bound only once by transmitter molecules. We show here that the decay of evoked non-NMDA synaptic currents can reflect presynaptic factors, in particular, the prolonged action of transmitter at postsynaptic receptors under conditions of enhanced transmitter… CONTINUE READING

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