Presynaptic imidazoline receptors. New developments in characterization and classification.

@article{Gthert1999PresynapticIR,
  title={Presynaptic imidazoline receptors. New developments in characterization and classification.},
  author={Manfred G{\"o}thert and Michael Br{\"u}ss and Heinz B{\"o}nisch and Gerhard J Molderings},
  journal={Annals of the New York Academy of Sciences},
  year={1999},
  volume={881},
  pages={171-84}
}
Presynaptic imidazoline receptors (IRs) which inhibit norepinephrine (NE) release from sympathetic nerve endings have been identified in cardiovascular tissue of man, rabbit, rat, and guinea pig. They do not belong to one of the classical presynaptic inhibitory receptor classes such as alpha 2-adrenoceptors or H3 histamine receptors, and there is also no relation to I1- and I2-imidazoline binding sites. Segments of human right atrial appendages preincubated with [3H]NE were used to determine… CONTINUE READING