Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors.

@article{Marinelli2003PresynapticFO,
  title={Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors.},
  author={Silvia Marinelli and Vincenzo Di Marzo and Nicola Berretta and Isabel Matias and Mauro Maccarrone and Giorgio Bernardi and Nicola Biagio Mercuri},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 8},
  pages={3136-44}
}
Growing evidence regarding the function of vanilloid receptor-1 (VR1) in the brain suggests potential central roles of this receptor, previously described to occur primarily in peripheral sensory neurons. In the present study, we used electrophysiological and biochemical techniques to investigate the function and the endogenous stimulation of VR1 in dopaminergic neurons of the substantia nigra pars compacta (SNc). The VR1 agonist capsaicin increased the frequency of both TTX-sensitive and… CONTINUE READING
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Presynaptic effects of VR1 activation in the ventral midbrain

  • S Marinelli, N Berretta, G Bernardi, NB Mercuri
  • Soc Neurosci Abstr
  • 2002
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