Presynaptic dopamine receptors: Insensitivity to kainic acid and the development of supersensitivity following chronic haloperidol

@article{Bannon1980PresynapticDR,
  title={Presynaptic dopamine receptors: Insensitivity to kainic acid and the development of supersensitivity following chronic haloperidol},
  author={Michael J Bannon and Edward Bradshaw Bunney and Jeffrey R. Zigun and Lana R. Skirboll and Robert H. Roth},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1980},
  volume={312},
  pages={161-165}
}
The effects of kainic acid lesions and chronic haloperidol treatment on rat striatal dopaminergic presynaptic receptors were studied. Following the γ-butyrolactone-induced inhibition of dopaminergic impulse flow, and after dopa decarboxylase inhibition, dopa accumulation and its reversal by dopamine agonists was measured in vivo.3H-apomorphine (a dopamine receptor ligand with purported presynaptic specificity) was used for in vitro binding experiments. Presynaptic dopamine receptors, as… CONTINUE READING

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Dopaminergic neurons: Role of presynaptic receptors in the regulation of transmitter biosynthesis

  • M. C. Nowycky, R. H. Roth
  • Prog. Neuro-Psychopharmacol
  • 1978
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