Presynaptic calcium channel inhibition underlies CB₁ cannabinoid receptor-mediated suppression of GABA release.

@article{Szab2014PresynapticCC,
  title={Presynaptic calcium channel inhibition underlies CB₁ cannabinoid receptor-mediated suppression of GABA release.},
  author={Gergely G. Szab{\'o} and Nora Lenkey and No{\'e}mi Holderith and Tibor Andr{\'a}si and Zoltan Nusser and Norbert H{\'a}jos},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 23},
  pages={7958-63}
}
CB1 cannabinoid receptors (CB1) are located at axon terminals and effectively control synaptic communication and thereby circuit operation widespread in the CNS. Although it is partially uncovered how CB1 activation leads to the reduction of synaptic excitation, the mechanisms of the decrease of GABA release upon activation of these cannabinoid receptors… CONTINUE READING