Presynaptic and postsynaptic dopaminergic binding densities in the nigrostriatal and mesocortical systems in early Parkinson's disease: a double-tracer positron emission tomography study.

@article{Ouchi1999PresynapticAP,
  title={Presynaptic and postsynaptic dopaminergic binding densities in the nigrostriatal and mesocortical systems in early Parkinson's disease: a double-tracer positron emission tomography study.},
  author={Yasuomi Ouchi and Toshihiko Kanno and Hiroyuki Okada and E. Yoshikawa and Masami Futatsubashi and Shuji Nobezawa and Tatsuo Torizuka and Masanobu Sakamoto},
  journal={Annals of neurology},
  year={1999},
  volume={46 5},
  pages={
          723-31
        }
}
To investigate changes in the relation between presynaptic and postsynaptic dopaminergic functions in vivo in both nigrostriatal and mesocortical systems in Parkinson's disease (PD), 10 drug-naive early PD patients were studied twice using positron emission tomography with [11C]CFT (dopamine transporter probe) followed by [11C]SCH 23390 (D1 receptor probe). Regional binding potentials (k3/k4) of [11C]CFT and [11C]SCH 23390 in the striatum (nigrostriatal system) and the orbitofrontal cortex… CONTINUE READING
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