Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease.

  title={Presynaptic alpha-synuclein aggregation in a mouse model of Parkinson's disease.},
  author={Kateri J. Spinelli and Jonathan E. Taylor and Valerie R. Osterberg and Madeline J. Churchill and Eden Pollock and Cynthia A. Moore and Charles K. Meshul and Vivek K. Unni},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={34 6},
Parkinson's disease and dementia with Lewy bodies are associated with abnormal neuronal aggregation of α-synuclein. However, the mechanisms of aggregation and their relationship to disease are poorly understood. We developed an in vivo multiphoton imaging paradigm to study α-synuclein aggregation in mouse cortex with subcellular resolution. We used a green fluorescent protein-tagged human α-synuclein mouse line that has moderate overexpression levels mimicking human disease. Fluorescence… CONTINUE READING
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