Presynaptic Type III Neuregulin1-ErbB signaling targets α7 nicotinic acetylcholine receptors to axons

@article{Hancock2008PresynapticTI,
  title={Presynaptic Type III Neuregulin1-ErbB signaling targets α7 nicotinic acetylcholine receptors to axons},
  author={Melissa L. Hancock and Sarah E. Canetta and Lorna W Role and David A Talmage},
  journal={The Journal of Cell Biology},
  year={2008},
  volume={181},
  pages={511 - 521}
}
Type III Neuregulin1 (Nrg1) isoforms are membrane-tethered proteins capable of participating in bidirectional juxtacrine signaling. Neuronal nicotinic acetylcholine receptors (nAChRs), which can modulate the release of a rich array of neurotransmitters, are differentially targeted to presynaptic sites. We demonstrate that Type III Nrg1 back signaling regulates the surface expression of alpha7 nAChRs along axons of sensory neurons. Stimulation of Type III Nrg1 back signaling induces an increase… CONTINUE READING
Highly Cited
This paper has 140 citations. REVIEW CITATIONS

6 Figures & Tables

Topics

Statistics

05010015020082009201020112012201320142015201620172018
Citations per Year

140 Citations

Semantic Scholar estimates that this publication has 140 citations based on the available data.

See our FAQ for additional information.