Presynaptic Specificity of Endocannabinoid Signaling in the Hippocampus

  title={Presynaptic Specificity of Endocannabinoid Signaling in the Hippocampus},
  author={Rachel I. Wilson and George Kunos and Roger A Nicoll},
Endocannabinoids are retrograde messengers released by neurons to modulate the strength of their synaptic inputs. Endocannabinoids are thought to mediate the suppression of GABA release that follows depolarization of a hippocampal CA1 pyramidal neuron-termed "depolarization-induced suppression of inhibition" (DSI). Here, we report that DSI is absent in mice which lack cannabinoid receptor-1 (CB1). Pharmacological and kinetic evidence suggests that CB1 activation inhibits presynaptic Ca2… CONTINUE READING
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Evidence for a new G protein-coupled cannabinoid receptor

  • C. S. Breivogel, G. Griffin, V. DiMarzo, B. R. Martin
  • Somouse brain. Mol. Pharm
  • 2001
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Postsynaptic spike firing reduces calcium channel signalling system

  • B. E. Alger
  • Curr . Opin . Neurobiol .
  • 1992
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