Presynaptic N-type and P/Q-type Ca2+ channels mediating synaptic transmission at the calyx of Held of mice.

@article{Ishikawa2005PresynapticNA,
  title={Presynaptic N-type and P/Q-type Ca2+ channels mediating synaptic transmission at the calyx of Held of mice.},
  author={Taro Ishikawa and Masahiro Kaneko and Hee-sup Shin and Tomoyuki Takahashi},
  journal={The Journal of physiology},
  year={2005},
  volume={568 Pt 1},
  pages={199-209}
}
At the nerve terminal, both N- and P/Q-type Ca2+ channels mediate synaptic transmission, with their relative contribution varying between synapses and with postnatal age. To clarify functional significance of different presynaptic Ca2+ channel subtypes, we recorded N-type and P/Q-type Ca2+ currents directly from calyces of Held nerve terminals in alpha1A-subunit-deficient mice and wild-type (WT) mice, respectively. The most prominent feature of P/Q-type Ca2+ currents was activity-dependent… CONTINUE READING

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