Presynaptic External Calcium Signaling Involves the Calcium-Sensing Receptor in Neocortical Nerve Terminals

@inproceedings{Chen2010PresynapticEC,
  title={Presynaptic External Calcium Signaling Involves the Calcium-Sensing Receptor in Neocortical Nerve Terminals},
  author={Wenyan Chen and Jeremy B. Bergsman and Xiaohua Wang and Gawain Gilkey and Carol-Ren{\'e}e Pierpoint and Erin A. Daniel and Emmanuel M. Awumey and Philippe Dauban and Robert H Dodd and Martial Ruat and Stephen M Smith},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Nerve terminal invasion by an axonal spike activates voltage-gated channels, triggering calcium entry, vesicle fusion, and release of neurotransmitter. Ion channels activated at the terminal shape the presynaptic spike and so regulate the magnitude and duration of calcium entry. Consequently characterization of the functional properties of ion channels at nerve terminals is crucial to understand the regulation of transmitter release. Direct recordings from small neocortical nerve… CONTINUE READING