Presynaptic Cyclic Nucleotide-Gated Ion Channels Modulate Neurotransmission in the Mammalian Olfactory Bulb

@article{Murphy2003PresynapticCN,
  title={Presynaptic Cyclic Nucleotide-Gated Ion Channels Modulate Neurotransmission in the Mammalian Olfactory Bulb},
  author={Gabe J Murphy and Jeffry S. Isaacson},
  journal={Neuron},
  year={2003},
  volume={37},
  pages={639-647}
}
Cyclic nucleotide-gated channels (CNGCs) on the dendritic cilia of olfactory receptor neurons (ORNs) are critical for sensory transduction in the olfactory system. Do CNGCs also play a role in the axons and/or nerve terminals of ORNs? We find that the cyclic nucleotides cAMP and cGMP can both facilitate and depress synaptic transmission between olfactory nerve fibers and their targets in olfactory bulb glomeruli. Cyclic nucleotides increase intracellular Ca(2+) in ORN terminals and enhance… CONTINUE READING