Presynaptic Ca2+ channels – integration centers for neuronal signaling pathways

@article{Evans2006PresynapticCC,
  title={Presynaptic Ca2+ channels – integration centers for neuronal signaling pathways},
  author={Rhian M. Evans and Gerald W Zamponi},
  journal={Trends in Neurosciences},
  year={2006},
  volume={29},
  pages={617-624}
}
Calcium influx into presynaptic nerve terminals via voltage-gated Ca2+ channels is an essential step in neurotransmitter release. The predominant Ca2+ channel species in synaptic nerve terminals are P/Q-type and N-type channels, with their relative levels of expression varying across the nervous system. The different distributions of these two channel subtypes are reflected in their distinct physiological and pathological roles, yet their activity is regulated by common mechanisms and both… CONTINUE READING
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