Presynaptic Ca2+ buffers control the strength of a fast post-tetanic hyperpolarization mediated by the α3 Na+/K+-ATPase

@article{Kim2007PresynapticCB,
  title={Presynaptic Ca2+ buffers control the strength of a fast post-tetanic hyperpolarization mediated by the α3 Na+/K+-ATPase},
  author={Jun Hee Kim and I. A. Sizov and Maxim Dobretsov and Henrique Ralph von Gersdorff},
  journal={Nature Neuroscience},
  year={2007},
  volume={10},
  pages={196-205}
}
The excitability of CNS presynaptic terminals after a tetanic burst of action potentials is important for synaptic plasticity. The mechanisms that regulate excitability, however, are not well understood. Using direct recordings from the rat calyx of Held terminal, we found that a fast Na+/K+-ATPase (NKA)-mediated post-tetanic hyperpolarization (PTH) controls the probability and precision of subsequent firing. Notably, increasing the concentration of internal Ca2+ buffers or decreasing Ca2… CONTINUE READING
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